Dextran Sulfate Sodium Salt, Colitis Grade (36,000 to 50,000), MP Biomedicals™

Induces severe colitis (inflammatory bowel disease) in laboratory animals

Supplier:  MP Biomedicals, Inc 0216011010

Catalog No. ICN16011010

Description

Induces severe colitis (inflammatory bowel disease) in laboratory animals

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to trigger colitis in mice and rats when administered in drinking water. DSS binds to medium-chain-length fatty acids in the colon and induces intestinal inflammation. Colitis-grade DSS (MW = 36,000 to 50,000) from MP Bio is one of the most widely used products based on peer reviewed scientific publications.

• Induces severe colitis (inflammatory bowel disease)
• Highest sulfur content – 19%
• Highest chirality - +104° of specific rotation
• Lowest pH – 6.2 at 1% solution

Specifications

• Color: White
• pH: 5 to 7.11 (1% aqueous solution)
• CAS: 9011-18-1
• Melting Point: 92°C
• MDL Number: MFCD00081551
• Quantity: 10 g
• SMILES: *-OC[C@H]1O[C@H](OC[C@H]2O[C@H](-*)[C@H](O[*])[C@@H](O[*])[C@@H]2O[*])[C@H](O[*])[C@@H](O-*)[C@@H]1O[*]
• Molecular Weight (g/mol): 40,000
• Grade: Colitis Grade
• Packaging: Plastic Container

• Chemical Name or Material: Dextran Sulfate Sodium Salt
• Physical Form: Powder
• Boiling Point: 310°C
• Molecular Formula: (C6H7O5)m(C6H7O5)n
• Solubility Information: Soluble in water
• InChI Key: BLFLLBZGZJTVJG-UHFFFAOYSA-N
• IUPAC Name: Dextran sulfate sodium salt
• For Use With (Application): Used for inducing ulcerative colitis in animals and extensively to study colon cancer developing in relation to colonic inflammation
• Moisture: <10%

Safety and Handling

storageNote1 : Store at Room Temperature (15°C to 30°C)

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use.