Hydroxyurea, 98%, Thermo Scientific Chemicals

Description

Hydroxyurea, 98%, CAS # 127-07-1, is a compound with antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities. It shows inhibitory activity against nucleic acid synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Hydroxyurea is a member of the class of urea that shows antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities.

• It has inhibitory activity against nucleic acid synthesis.

• It also inhibits ribonucleoside diphosphate reductase, an enzyme necessary to convert ribonucleoside diphosphate into deoxyribonucleoside diphosphate, preventing cells from leaving the G1/S phase of the cell cycle

Applications

• Hydroxyurea has an anti-retroviral activity, inhibiting human immunodeficiency virus type 1 (HIV-1) DNA synthesis in peripheral blood lymphocytes, decreasing the amount of intracellular deoxynucleotides

• This compound also has a radio sensitizing activity, maintaining cells in the radiation-sensitive G1 cell cycle phase and, consequently, interfering with DNA repair

• It has been used for cell cycle synchronization in human breast carcinoma cells

• This compound presents inhibitory activity in cell adhesion and motility assay in ccRCC Caki (HTB-47) and CD9 knockdown cells

Specifications

Chemical Identifiers

• CAS: 127-07-1
• Molecular Formula: CH₄N₂O₂
• Molecular Weight (g/mol): 76.04
• MDL Number: MFCD00007943
• InChI Key: VSNHCAURESNICA-UHFFFAOYSA-N
• Synonym: hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid
• PubChem CID: 3657
• ChEBI: CHEBI:44423
• IUPAC Name: hydroxyurea
• SMILES: C(=O)(N)NO

• Melting Point: 142°C to 146°C
• Color: White
• Loss on Drying: 1% max. (1 g, 60°C) (< 0.7 kPa)
• Infrared Spectrum: Authentic
• Assay Percent Range: 97.5% min. (on dried substance) (Iodometry)
• Packaging: Glass bottle
• Linear Formula: HONHCONH₂
• Quantity: 100 g
• Beilstein: 03, 95
• Merck Index: 15, 4888
• Solubility Information: Solubility in water: freely soluble. Other solubilities: freely soluble in hot alcohol
• Formula Weight: 76.04
• Percent Purity: 98%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Hydroxyurea

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement: May cause genetic defects. May damage the unborn child.
Precautionary Statement	GHS P Statement: Obtain special instructions before use. IF exposed or concerned: Get medical advice/attention. WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
EINECSNumber	204-821-7

SDS

RUO – Research Use Only