G418 disulfate, Cell Culture Reagent, Thermo Scientific Chemicals

Description

G418 sulfate, geneticin, CAS # 108321-42-2, is an antibiotic closely related to Gentamicin B, the common aminoglycoside antibiotic.

G418 disulfate is an aminoglycoside that is toxic to bacteria, yeast, protozoans and helminths. It prevents protein synthesis by blocking the elongation step in prokaryotic and eukaryotic ribosomes. It is used as a selection agent for G418 resistant bacteria or fungi after transformation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description
• G418 sulfate (geneticin) is an aminoglycoside antibiotic isolated from Micromonospora rhodorangea
• G418 is a bacteriostatic that prevents polypeptide formation by inhibiting the elongation step of polypeptide synthesis
Applications
• G418 sulfate can be used for selection of genetically engineered cells in both eukaryotes and prokaryotes
• Laboratory grade for applications such as biochemistry

Specifications

Chemical Identifiers

• CAS: 108321-42-2
• Molecular Formula: C20H44N4O18S2
• Molecular Weight (g/mol): 692.70
• MDL Number: MFCD00058314
• InChI Key: UHEPSJJJMTWUCP-KETIWVBHNA-N
• Synonym: Geneticin disulfate
• PubChem CID: 134129582
• SMILES: OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)OC[C@]1(C)O

• Type: G418 Disulfate
• Physical Form: Powder
• Solubility Information: Soluble in water.
• IUPAC Name: (2R,3S,4R,5R,6S)-5-amino-6-{[(1R,2S,3S,4R,6S)-4,6-diamino-3-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-(1-hydroxyethyl)oxane-3,4-diol; bis(sulfuric acid)
• Formula Weight: 692.71
• Grade: Cell Culture
• Color: White
• Quantity: 1 g
• Chemical Name or Material: G418 disulfate

Safety and Handling

Hazard Category	H317-H334
Precautionary Statement	P261-P272-P280g-P285-P302+P352-P304+P341-P333+P313-P342+P311-P363-P501c
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only