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C-DIM 12, Tocris Bioscience™

Catalog No. 582150
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Nurr1 activator; inhibits NF-κB-dependent gene expression

Nurr1 activator. Inhibits NF-κB and cytokine expression in microglial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. Neuroprotective in a mouse Parkinson's disease model. Orally bioavailable.

Chemical Identifiers

CAS 178946-89-9
Molecular Formula C23H17ClN2
Molecular Weight (g/mol) 356.85
MDL Number MFCD05625919
InChI Key LTLRXTDMXOFBDW-UHFFFAOYSA-N
Synonym C-DIM 12
PubChem CID 5302583
IUPAC Name 3-[(4-chlorophenyl)(1H-indol-3-yl)methyl]-1H-indole
SMILES ClC1=CC=C(C=C1)C(C1=CNC2=CC=CC=C12)C1=CNC2=CC=CC=C12

Specifications

Linear Formula C23H17ClN2
Quantity 50 mg
Solubility Information Soluble to 100mM in DMSO and to 100mM in ethanol
Formula Weight 356.85
Percent Purity >98%
Physical Form Solid
Chemical Name or Material 3,3'-[(4-Chlorophenyl)methylene]bis[1H-indole]

Safety and Handling

Recommended Storage Store at −20°C
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