Hs02980882_cn

• Gene Symbol: ALOX12
• Assay Reference Genome Location: Chr.17:7010346 on build GRCh38
• Cytoband: 17p13.1

Target Gene Details

• Entrez Gene ID: 239
• Gene Name: arachidonate 12-lipoxygenase, 12S type
• Gene Aliases: 12-LOX, 12S-LOX, LOG12
• Location: Chr.17:6993791-7010736 on Build GRCh38
• Assay Gene Location: Within Exon 14

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12	NM_000697.2	14	1968	NP_000688.2
	XM_011523780.2	13	4035	XP_011522082.1
	AF143883.1	3	633	AAD32700.1
	BC069557.1	14	1946	AAH69557.1
	M35418.1	14	1956	AAA60056.1
	M58704.1	14	1948	AAA59523.1
	M62982.1	14	1968	AAA51533.1

Target Gene Details

• Entrez Gene ID: 100506713
• Gene Name: ALOX12 antisense RNA 1
• Gene Aliases: -
• Location: Chr.17:6985123-7012334 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12-AS1	NR_040089.1
	BI559919.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422288	Chr.17:6789933 - 7646709 on Build GRCh38	Deletion	SENP3 ASGR2 PLSCR3 TMEM102 DLG4 ALOX12-AS1 FXR2 C17orf74 KCTD11 CTDNEP1 SNORA48 ZBTB4 GPS2 CHRNB1 SOX15 SLC16A13 ACADVL SAT2 SLC35G6 TNFSF12-TNFSF13 SPEM1 MPDU1 CLDN7 TNFSF13 LOC107983988 TMEM256-PLSCR3 NLGN2 NEURL4 RNASEK-C17orf49 MIR324 ALOX12 MIR497 MIR497HG CLEC10A ALOX12P2 C17orf49 EIF4A1 SNORD10 TNK1 MIR195 DVL2 BCL6B TMEM256 ELP5 TEKT1 ATP1B2 SLC2A4 LOC100996842 CD68 FBXO39 PHF23 ASGR1 SENP3-EIF4A1 EIF5A TNFSF12 SHBG GABARAP YBX2 ACAP1 POLR2A TMEM95 SLC16A11 FGF11 RNASEK SNORA67
nsv574322	Chr.17:7010333 - 7689462 on Build GRCh38	Loss	SENP3 ASGR2 PLSCR3 TMEM102 DLG4 ALOX12-AS1 FXR2 C17orf74 KCTD11 CTDNEP1 SNORA48 ZBTB4 GPS2 CHRNB1 SOX15 SLC16A13 ACADVL SAT2 SLC35G6 TNFSF12-TNFSF13 SPEM1 MPDU1 CLDN7 TNFSF13 LOC107983988 TMEM256-PLSCR3 NLGN2 NEURL4 RNASEK-C17orf49 MIR324 ALOX12 MIR497 MIR497HG CLEC10A C17orf49 EIF4A1 SNORD10 TNK1 MIR195 DVL2 BCL6B TMEM256 ELP5 ATP1B2 SLC2A4 LOC100996842 CD68 PHF23 ASGR1 SENP3-EIF4A1 EIF5A TNFSF12 SHBG GABARAP YBX2 ACAP1 POLR2A TMEM95 SLC16A11 FGF11 WRAP53 RNASEK SNORA67 TP53

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

movement of cell or subcellular component
aging
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
arachidonic acid metabolic process
lipoxygenase pathway
fatty acid oxidation
positive regulation of cell growth
positive regulation of cell migration
superoxide anion generation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
linoleic acid metabolic process
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of vasodilation
positive regulation of smooth muscle cell proliferation
hepoxilin metabolic process
hepoxilin biosynthetic process
positive regulation of mitochondrial depolarization
establishment of skin barrier
cellular response to lipid
reactive oxygen species metabolic process
negative regulation of platelet aggregation
leukotriene A4 metabolic process
lipoxin metabolic process
lipoxin A4 biosynthetic process
lipoxin B4 biosynthetic process

Function(s)

arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
linoleate 13S-lipoxygenase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hepoxilin-epoxide hydrolase activity
hepoxilin A3 synthase activity