Hs00212011_cn

• Gene Symbol: ALOX12
• Assay Reference Genome Location: Chr.17:7010466 on build GRCh38
• Cytoband: 17p13.1

Target Gene Details

• Entrez Gene ID: 239
• Gene Name: arachidonate 12-lipoxygenase, 12S type
• Gene Aliases: 12-LOX, 12S-LOX, LOG12
• Location: Chr.17:6993791-7010736 on Build GRCh38
• Assay Gene Location: Within Exon 14

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12	NM_000697.2	14	2088	NP_000688.2
	XM_011523780.2	13	4155	XP_011522082.1
	AF143883.1	3	753	AAD32700.1
	BC069557.1			AAH69557.1
	M35418.1	14	2076	AAA60056.1
	M58704.1	14	2068	AAA59523.1
	M62982.1	14	2088	AAA51533.1

Target Gene Details

• Entrez Gene ID: 100506713
• Gene Name: ALOX12 antisense RNA 1
• Gene Aliases: -
• Location: Chr.17:6985123-7012334 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12-AS1	NR_040089.1
	BI559919.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422288	Chr.17:6789933 - 7646709 on Build GRCh38	Deletion	FBXO39 CLDN7 SOX15 TMEM102 ASGR2 GABARAP FGF11 RNASEK SENP3-EIF4A1 ATP1B2 TNK1 ASGR1 ZBTB4 NLGN2 SHBG MIR497 DLG4 ACADVL MPDU1 SPEM1 TMEM95 POLR2A SNORD10 NEURL4 LOC107983988 YBX2 FXR2 GPS2 C17orf74 MIR324 SLC2A4 SLC35G6 MIR497HG TMEM256-PLSCR3 BCL6B CD68 ACAP1 TMEM256 SLC16A11 TNFSF12-TNFSF13 ALOX12P2 SENP3 DVL2 LOC100996842 SAT2 PHF23 ALOX12 SNORA48 TNFSF12 CHRNB1 PLSCR3 RNASEK-C17orf49 CTDNEP1 ALOX12-AS1 EIF5A C17orf49 TEKT1 ELP5 TNFSF13 EIF4A1 SLC16A13 SNORA67 KCTD11 MIR195 CLEC10A
nsv574322	Chr.17:7010333 - 7689462 on Build GRCh38	Loss	CLDN7 SOX15 TMEM102 ASGR2 GABARAP FGF11 RNASEK SENP3-EIF4A1 ATP1B2 TNK1 ASGR1 ZBTB4 NLGN2 SHBG MIR497 DLG4 ACADVL MPDU1 SPEM1 TMEM95 POLR2A SNORD10 NEURL4 LOC107983988 YBX2 FXR2 GPS2 C17orf74 MIR324 SLC2A4 WRAP53 SLC35G6 MIR497HG TMEM256-PLSCR3 BCL6B CD68 ACAP1 TMEM256 SLC16A11 TNFSF12-TNFSF13 SENP3 DVL2 LOC100996842 SAT2 PHF23 ALOX12 SNORA48 TNFSF12 CHRNB1 PLSCR3 RNASEK-C17orf49 CTDNEP1 ALOX12-AS1 EIF5A C17orf49 ELP5 TNFSF13 EIF4A1 SLC16A13 SNORA67 TP53 KCTD11 MIR195 CLEC10A

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

movement of cell or subcellular component
aging
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
arachidonic acid metabolic process
lipoxygenase pathway
fatty acid oxidation
positive regulation of cell growth
positive regulation of cell migration
superoxide anion generation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
linoleic acid metabolic process
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of vasodilation
positive regulation of smooth muscle cell proliferation
hepoxilin metabolic process
hepoxilin biosynthetic process
positive regulation of mitochondrial depolarization
establishment of skin barrier
cellular response to lipid
reactive oxygen species metabolic process
negative regulation of platelet aggregation
leukotriene A4 metabolic process
lipoxin metabolic process
lipoxin A4 biosynthetic process
lipoxin B4 biosynthetic process

Function(s)

arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
linoleate 13S-lipoxygenase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hepoxilin-epoxide hydrolase activity
hepoxilin A3 synthase activity