Hs05513355_cn

• Gene Symbol: ALOX12
• Assay Reference Genome Location: Chr.17:7003851 on build GRCh38
• Cytoband: 17p13.1

Target Gene Details

• Entrez Gene ID: 239
• Gene Name: arachidonate 12-lipoxygenase, 12S type
• Gene Aliases: 12-LOX, 12S-LOX, LOG12
• Location: Chr.17:6993791-7010736 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12	NM_000697.2			NP_000688.2
	XM_011523780.2			XP_011522082.1
	BC069557.1			AAH69557.1
	M35418.1			AAA60056.1
	M58704.1			AAA59523.1
	M62982.1			AAA51533.1
	S68587.1			AAD14020.1
	S68588.1			AAD14021.1

Target Gene Details

• Entrez Gene ID: 100506713
• Gene Name: ALOX12 antisense RNA 1
• Gene Aliases: -
• Location: Chr.17:6985123-7012334 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ALOX12-AS1	NR_040089.1
	BI559919.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422288	Chr.17:6789933 - 7646709 on Build GRCh38	Deletion	TEKT1 GABARAP PLSCR3 MIR195 ACADVL SNORA67 ATP1B2 FBXO39 MPDU1 EIF4A1 CHRNB1 SAT2 SENP3-EIF4A1 SLC16A13 ALOX12P2 SLC16A11 ZBTB4 MIR497HG CLDN7 TNFSF13 POLR2A TMEM102 TNK1 TNFSF12 CD68 KCTD11 PHF23 SLC35G6 NLGN2 CTDNEP1 LOC107983988 RNASEK-C17orf49 SNORA48 TMEM256 MIR497 CLEC10A DLG4 DVL2 SOX15 YBX2 SENP3 GPS2 RNASEK C17orf49 LOC100996842 ACAP1 FGF11 TMEM95 ALOX12 TMEM256-PLSCR3 SPEM1 ALOX12-AS1 C17orf74 ASGR1 SNORD10 MIR324 SLC2A4 EIF5A ASGR2 BCL6B ELP5 FXR2 NEURL4 SHBG TNFSF12-TNFSF13

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

movement of cell or subcellular component
aging
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
arachidonic acid metabolic process
lipoxygenase pathway
fatty acid oxidation
positive regulation of cell growth
positive regulation of cell migration
superoxide anion generation
negative regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
linoleic acid metabolic process
positive regulation of endothelial cell differentiation
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of vasodilation
positive regulation of smooth muscle cell proliferation
hepoxilin metabolic process
hepoxilin biosynthetic process
positive regulation of mitochondrial depolarization
establishment of skin barrier
cellular response to lipid
reactive oxygen species metabolic process
negative regulation of platelet aggregation
leukotriene A4 metabolic process
lipoxin metabolic process
lipoxin A4 biosynthetic process
lipoxin B4 biosynthetic process

Function(s)

arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
linoleate 13S-lipoxygenase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hepoxilin-epoxide hydrolase activity
hepoxilin A3 synthase activity