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Abnova™ Human lg-kappa/lg-lambda CISH Probe
Human lg-kappa/lg-lambda CISH Probe is designed for the simultaneous qualitative detection of human Ig-kappa and Ig-lambda light chain mRNA in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
Supplier: Abnova™ CG0031
Description
The probe is intended to be used in combination with the Human Ig-kappa/Ig-lambda CISH Permanent Kit, which provides necessary reagents for specimen pretreatment and post-hybridization processing.A positive reactivity in plasma B-cells is indicated by cytoplasmic staining. In lymphoid tissue, the normal kappa-to-lambda ratio is roughly 2:1, an indication for monoclonality is given if the kappa-to-lambda ratio is greater than 3:1 or less than 0.3:1. Visualization of signals should be performed at least at 100-fold magnification resulting in easily visible signals. Do not evaluate areas of necrosis, overlapping nuclei, over-digested nuclei, and nuclei with weak signal intensity.
Specifications
| Reagent Provided: 1.Digoxigenin-labeled oligonucleotides targeting mRNA sequences encoding Ig-kappa light chain constant regions. 2. Biotin-labeled oligonucleotides targeting mRNA sequences encoding Ig-lambda light chain constant regions. |
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| The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (55°C) and mix briefly before use. | |
| CISH-P |
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