Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Abnova™ CDKN2A/CEN9 CISH Probe
CDKN2A/CEN9 CISH Probe is designed for the qualitative detection of human CDKN2A gene as well as chromosome 9 classical satellites in formalin-fixed, paraffin-embedded specimens by chromogenic in situ hybridization (CISH).
Supplier: Abnova™ CG0004
Description
The probe is intended to be used in combination with the CISH Implementation Kit 2, which provides necessary reagents for specimen pretreatment and post-hybridization processing.Hybridization signals of digoxigenin-labeled polynucleotides appear as dark green colored distinct dots (CDKN2A gene), and dinitrophenyl-labeled polynucleotides appear as bright red colored distinct dots (CEN 9).
Normal situation: In interphases of normal cells or cells without a aberrations involving the 9p21.3 band, two green and two red signals per nuclei appear.
Aberrant situation: In a cell with deletions affecting the CDKN2A locus, a reduced number of green signals will be observed. Deletions affecting only parts of the CDKN2A gene might result in a normal signal pattern with green signals of reduced size.
Other signal distribution may be observed in some abnormal samples which might result in a different signal pattern than described above, indicating variant rearrangements.
Unexpected signal patterns should be further investigated.
Specifications
The product is ready-to-use. No reconstitution, mixing, or dilution is required. Bring probe to room temperature (18 to 25°C) and mix briefly before use. | |
CISH-Ce |
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction