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Berberine chloride, Thermo Scientific Chemicals
Description
Berberine is an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme Cox-2 (cyclooxygenase-2) which is abundantly expressed in colon cancer cells. Also inhibits c-Jun (Activator Protein 1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Soluble in dimethyl sulfoxide (74 mg/ml at 25°C), ethanol (<1mg/mL at 25°C), water (<1mg/mL at 25°C), and methanol.
Notes
Store at -20°C. Incompatible with oxidizing agents. Protect from heat.
Specifications
| Color | Yellow to Orange |
| Quantity | 5 g |
| Beilstein | 3836585 |
| Solubility Information | Soluble in dimethyl sulfoxide (74mg/ml at 25°C),ethanol (<1mg/ml at 25°C),water (<1mg/ml at 25°C),and methanol. |
| Formula Weight | 371.82 |
| Physical Form | Powder |
| Chemical Name or Material | Berberine chloride |
Safety and Handling
| EINECSNumber | 211-195-9 |
| TSCA | Yes |
| Recommended Storage | Keep cold |
RUO – Research Use Only
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