Transitioning from Academia to Cell Therapy
By Mary Kay Bates,
M.S., Senior Global Cell Culture Specialist
There is much excitement and optimism for treating cancer, neurological and muscular disorders, orphan diseases, and more with new cell and gene therapy technologies. In 2018, two CAR-T approaches were approved by the U.S. Federal Drug Administration, with many more to follow. These successes have been built on many years of painstaking research across multiple disciplines and institutions.
In bringing new cell and gene therapies to the clinic, scientific leaders transitioning to therapy or production for the first time may find the wealth of planning and the regulatory environment required to be overwhelming. But there is good news: the essential cell culture equipment that you have used in your lab and trusted with your work for many years is perfectly positioned to transition with you.
Thermo Scientific equipment has been at the core of cell culture for a reason: our CO2 incubators, biological safety cabinets (BSCs), and centrifuges are designed and engineered through decades of innovative leadership. Our technologies are tested and validated to ensure the protection of your cells and your work.
Thermo Scientific CO2 Incubators offer multiple large-capacity solutions for higher-volume and scale-up applications. The Thermo Scientific Heracell VIOS 250i CO2 Incubator provides a premium cleanroom-compatible solution where cultures can grow in a precisely controlled environment. Optional variable oxygen control allows for precise control, which is critical with sensitive cells. ISO Class 5 HEPA filtration for airborne contamination protection and the proven, overnight Thermo Scientific Steri-Run 180°C sterilization cycle help protect against contamination.
The new Thermo Scientific HeraSafe 2030i Biological Safety Cabinet incorporates an easy-to-use graphic user interface that clearly shows equipment status at all times. Autonomous self-managing safety features provide secure knowledge that precious samples are protected during this stage of the workflow. Connectivity ready, the Herasafe 2030i can additionally provide data and remote status checking.
Cellular separation is a critical and essential step in your process and it is important to consider and select the correct specification. The proper speed and g-force, adaptability to your sample containers, our biocontainment certification, ease of use and reliability, and mobility in the cleanroom are all important features that Thermo Scientific general-purpose centrifuges offer.
CryoMed control-rate freezers use a patented LN2 delivery system to precisely move samples through the phases of the cryopreservation process. This is instrumental in ensuring cell line viability. Once frozen, samples can be placed into long-term cryogenic storage or shipped with our Arctic Express line of cryogenic shippers.
All of these Thermo Scientific products are accompanied by a solid portfolio of validation and support services to ensure uptime and compliance.
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