Thermo Scientific Chemicals Trifluoroacetic acid, biochemical grade, 99.5+%

Description

Used to cleave peptide blocking groupsThe combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Used to cleave peptide blocking groupsThe combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Solubility
Miscible with ether, acetone, ethanol, benzene, hexane and carbon tetrachloride.

Notes
Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Specifications

• Melting Point: -15°C
• Boiling Point: 72°C to 73°C
• UN Number: UN2699
• Beilstein: 742035
• Merck Index: 14,9681
• Solubility Information: Miscible with ether,acetone,ethanol,benzene,hexane and carbon tetrachloride.
• Formula Weight: 114.02
• Percent Purity: ≥99.5%
• Grade: Biochemical
• Density: 1.48
• Quantity: 250 g
• Odor: Pungent
• Refractive Index: 1.284
• Sensitivity: Hygroscopic
• Chemical Name or Material: Trifluoroacetic acid

Safety and Handling

Hazard Category	H290-H314-H332-H335
Hazard Statement	GHS H Statement H314-H332 Causes severe skin burns and eye damage. Harmful if inhaled.
Precautionary Statement	P234-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P390-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: I; Proper Shipping Name: TRIFLUOROACETIC ACID
EINECSNumber	200-929-3
RTECSNumber	AJ9625000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only