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  7. R 1530, Tocris Bioscience™

R 1530, Tocris Bioscience™

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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
882531-87-5
C18H14ClFN4O
356.785
UOVCGJXDGOGOCZ-UHFFFAOYSA-N
unii-xqj55r5ppq, xqj55r5ppq, 5-2-chlorophenyl-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo 3,4-b 1,4 benzodiazepine, kinome_3737, pyrazolo 3,4-b 1,4 benzodiazepine, 5-2-chlorophenyl-7-fluoro-1,2-dihydro-8-methoxy-3-methyl, r hplc, 5-2-chlorophenyl-1,2-dihydro-7-fluoro-8-methoxy-3-methyl-pyrazolo 3,4-b 1,4 benzodiazepine, 5-2-chlorophenyl-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo 3,4-b 1,4 benzodiazepine, 5-2-chlorophenyl-7-fluoro-8-methoxy-3-methyl-2,10-dihydrobenzo e pyrazolo 4,3-b 1,4 diazepine
11610113
5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine
CC1=C2C(=NC3=CC(=C(C=C3C(=N2)C4=CC=CC=C4Cl)F)OC)NN1
This item is not returnable. View return policy
882531-87-5
C18H14ClFN4O
356.785
UOVCGJXDGOGOCZ-UHFFFAOYSA-N
unii-xqj55r5ppq, xqj55r5ppq, 5-2-chlorophenyl-7-fluoro-1,2-dihydro-8-methoxy-3-methylpyrazolo 3,4-b 1,4 benzodiazepine, kinome_3737, pyrazolo 3,4-b 1,4 benzodiazepine, 5-2-chlorophenyl-7-fluoro-1,2-dihydro-8-methoxy-3-methyl, r hplc, 5-2-chlorophenyl-1,2-dihydro-7-fluoro-8-methoxy-3-methyl-pyrazolo 3,4-b 1,4 benzodiazepine, 5-2-chlorophenyl-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo 3,4-b 1,4 benzodiazepine, 5-2-chlorophenyl-7-fluoro-8-methoxy-3-methyl-2,10-dihydrobenzo e pyrazolo 4,3-b 1,4 diazepine
11610113
5-(2-chlorophenyl)-7-fluoro-8-methoxy-3-methyl-1,2-dihydropyrazolo[3,4-b][1,4]benzodiazepine
CC1=C2C(=NC3=CC(=C(C=C3C(=N2)C4=CC=CC=C4Cl)F)OC)NN1

Description

Multi-RTK inhibitor; inhibits angiogenesis

Multi-kinase inhibitor. Exhibits inhibitory activity against Chk2, KDR, FGFR, Aurora A kinase and Cdk2 (IC50 values are 24, 34, 50, 58 and 88 nM respectively). Also binds VEGFR-2, FGFR1 and PDGFRβ (Kd values are 0.015, 0.061 and 0.088 μM respectively). Displays antiproliferative activity in vitro; inhibits mitosis and angiogenesis. Orally bioavailable.
Quantity 50 mg
Formula Weight 356.78
Percent Purity >98%
Chemical Name or Material R 1530

Safety and Handling

Recommended Storage : Store at +4°C