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PF 04449613, >98%, Tocris Bioscience™

Catalog Number 591510
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Quantity:
10 mg
This item is not returnable. View return policy
1236858-52-8
C21H25N5O3
395.463
WEDCMPMDOVEMSV-CQSZACIVSA-N
d04jpg, pde 9 inhibitor alzheimer's disease, pde 9 inhibitor alzheimer's disease , pfizer, phosphodiesterase 9 inhibitor alzheimer's disease , pfizer, 1,5-dihydro-6-1r-1-3-phenoxy-1-azetidinyl ethyl-1-tetrahydro-2h-pyran-4-yl-4h-pyrazolo 3,4-d pyrimidin-4-one
46851937
1-(oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-2H-pyrazolo[3,4-d]pyrimidin-4-one
CC(C1=NC(=O)C2=CNN(C2=N1)C3CCOCC3)N4CC(C4)OC5=CC=CC=C5
This item is not returnable. View return policy
1236858-52-8
C21H25N5O3
395.463
WEDCMPMDOVEMSV-CQSZACIVSA-N
d04jpg, pde 9 inhibitor alzheimer's disease, pde 9 inhibitor alzheimer's disease , pfizer, phosphodiesterase 9 inhibitor alzheimer's disease , pfizer, 1,5-dihydro-6-1r-1-3-phenoxy-1-azetidinyl ethyl-1-tetrahydro-2h-pyran-4-yl-4h-pyrazolo 3,4-d pyrimidin-4-one
46851937
1-(oxan-4-yl)-6-[(1R)-1-(3-phenoxyazetidin-1-yl)ethyl]-2H-pyrazolo[3,4-d]pyrimidin-4-one
CC(C1=NC(=O)C2=CNN(C2=N1)C3CCOCC3)N4CC(C4)OC5=CC=CC=C5

Potent PDE9 inhibitor; brain penetrant

PF 04449613 is a potent PDE9 inhibitor (IC50 = 22 nM). Also exhibits a high affinity for cGMP (Km ∼170 nM). PF 04449613 reduces body fat in mice with diet-induced obesity, stimulating mitochondrial activity in brown and white fat, and improving cardiometabolic syndrome symptoms. Brain penetrant.
Linear Formula C21H25N5O3
Quantity 10 mg
Solubility Information Soluble to 100mM in DMSO and to 10mM in 1eq. HCl with gentle warming
Formula Weight 395.45
Chemical Name or Material 1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]
Grade >98%
Recommended Storage Store at −20°C
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