STEMCELL Technologies Mouse Recombinant M-CSF, Size: 100 µg
Supplier: STEMCELL Technologies 78059
Use macrophage colony-stimulating factor (M-CSF) to regulate the proliferation and differentiation of myeloid hematopoietic progenitor cells to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a homodimeric glycoprotein growth factor that is crucial to the development of tissue-resident macrophages in most tissues (Ginhoux & Jung Nat Rev Immunol, 2014) and regulates inflammatory responses together with other stimuli such as IFN-γ, LPS, and IL-4 (Murray et al. Immunity, 2014). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) (Hamilton JA J Leukoc Biol, 1997). Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam & Ghosh Tumour Biol, 2014). Mouse recombinant M-CSF from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 10 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Colony stimulating factor 1, CSF-1.
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok