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Invitrogen™ Dextran, Amino, 500,000 MW

Rigorous methods for removing as much unconjugated dye as practical, followed by sssay of dextran conjugates by thin-layer chromatography to help ensure absence of low molecular weight contaminants

Supplier: Invitrogen™ D7144

Catalog No. D7144

$174.00 / Each of 1

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Description

Labeled dextrans are hydrophilic polysaccharides most commonly used in microscopy studies to monitor cell division, track the movement of live cells, and to report the hydrodynamic properties of the cytoplasmic matrix. The labeled dextran is commonly introduced into the cells via microinjection. Dextrans are hydrophilic polysaccharides characterized by their moderate-to-high molecular weight, good water solubility, and low toxicity. They also generally exhibit low immunogeniticy. Dextrans are biologically inert due to their uncommon poly-(α-D-1,6-glucose) linkages, which render them resistant to cleavage by most endogenous cellular glycosidases.

Label (Ex/Em): None (can be conjugated to dyes and other molecules using amine-reactive moities)
Size: 500,000 MW
Succinimidyl coupling of dyes to dextran molecule, which, in most cases, results in neutral or anionic dextran
Reaction used to produce Rhodamine Green™ and Alexa Fluor™ 488 dextrans results in final product being neutral, anionic, or cationic
Common uses include neuronal tracing (anterograde and retrograde) in live cells
Cell lineage tracing in live cells
Neuroanatomical tracing
Examines intercellular communications (e.g., in gap junctions, during wound healing, and during embryonic development)
Investigates vascular permeability and blood-brain barrier integrity
Tracks endocytosis
Monitors acidification (some dextran-dye conjugates are pH-sensitive)
Studies hydrodynamic properties of cytoplasmic matrix

Cell Analysis, Cell Tracing and Tracking, General Cell Tracing, Neuronal Tracing

Order Info

Shipping Condition: Room temperature

Specifications

Product Type	Dextran
Content And Storage	Store at room temperature.
Shipping Condition	Room Temperature

Quantity	100 mg
Label or Dye	Unlabeled
Product Line	Invitrogen™

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

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For Research Use Only. Not for use in diagnostic procedures.

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