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  7. MK 0343, Tocris Bioscience™

MK 0343, Tocris Bioscience™

Catalog Number 441550
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
233275-76-8
C19H17F2N7O
397.39
MFCD22683821
GOIFCXRIFSYPFG-UHFFFAOYSA-N
unii-9vse02330i, 1,2,4-triazolo 4,3-b pyridazine, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, mk hplc, 5-7-cyclobutyl-3-2,6-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazo 4,3-b pyridazine
22609888
5-({[7-cyclobutyl-3-(2,6-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole
CN1N=CN=C1COC1=NN2C(C=C1C1CCC1)=NN=C2C1=C(F)C=CC=C1F
This item is not returnable. View return policy
233275-76-8
C19H17F2N7O
397.39
MFCD22683821
GOIFCXRIFSYPFG-UHFFFAOYSA-N
unii-9vse02330i, 1,2,4-triazolo 4,3-b pyridazine, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, mk hplc, 5-7-cyclobutyl-3-2,6-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 7-cyclobutyl-3-2,6-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazo 4,3-b pyridazine
22609888
5-({[7-cyclobutyl-3-(2,6-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1H-1,2,4-triazole
CN1N=CN=C1COC1=NN2C(C=C1C1CCC1)=NN=C2C1=C(F)C=CC=C1F

Description

Subtype-selective GABAA receptor partial agonist

Subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively); occupies the benzodiazepine site of GABAA receptors. Displays greater agonist efficacy at α3 compared to α1. Exhibits anxiolytic and non-sedating properties in rodent models. Brain penetrant.
Quantity 50 mg
Formula Weight 397.38
Percent Purity >99%
Chemical Name or Material MK 0343

Safety and Handling

Recommended Storage Store at +4°C
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