Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
MilliporeSigma™ TPC-1 Human Papillary Thyroid Carcinoma Cell Line
TPC-1 is a widely published and well-characterized cell line isolated from a papillary thyroid carcinoma of a female patient
Supplier: MilliporeSigma™ SCC147
Description
- The genome of TPC-1 contains the RET/PTC1 rearrangement found in approximately 20% of sporadic papillary carcinomas in adults
- TPC-1 harbors a silent polymorphism in H-RAS, and is wild-type for sequences of BRAF, CNBB1, EGFR, K-RAS, RAF-1, PI3K, and TRHB
- TPC-1 cells produce thyroglobulin (Tg) as well as expressing the thyroid differentiation marker PAX8 and the tumor progression factor podoplanin
- TPC-1 has been utilized as an in vitro model for human cytomegalovirus latency, a potential contributor for certain human cancers
- The TPC-1 cell line is thus an excellent system for investigating mechanisms of thyroid carcinogenesis
Specifications
Store in liquid nitrogen | |
Vial | |
≥ 1 x 106 cells/vial |
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?
Provide Content Correction