Invitrogen™ Human Osteopontin Synthetic Peptide
Supplier: Invitrogen™ PEP1622
SPP1 Synthetic Peptide, PEP-1622, from Invitrogen.Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D. This peptide corresponds to 18 amino acids near the amino terminus of SPP1.PEP-1622 can be used as a blocking peptide with polyclonal antibody PA5-34579. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37°C.
|Blocking Assay, Control|
|RUO - research use only|
|PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2|
|0.02% sodium azide|
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