Gibco™ HepaRG™ Cells, Cryopreserved

HepaRG™ Cells, Cryopreserved

Supplier:  Gibco™ HPRGC10

Catalog No. HPRGC10

Description

The HepaRG™ cell line is an immortalized hepatic cell line that retains many characteristics of primary human hepatocytes. HepaRG™ cells are terminally differentiated and provided in a convenient cryopreserved format. For scientists who need reproducible metabolism data, HepaRG™ cells are an in vitro tool that provides reproducible results in a metabolically complete and scalable system.

Obtain biologically relevant results from a metabolically complete system

Assess the drug-drug interaction potential of your compound

Experience reproducible results from a single population of cells

Biologically Relevant
HepaRG™ cells exhibit many characteristics of primary human hepatocytes including morphology, expression of key metabolic enzymes, expression of nuclear receptors, and drug transporters. Unlike HepG2 and Fa2N-4 cells, HepaRG™ cells have high P450 activity and complete expression of all nuclear receptors.

Predict Metabolism-based Drug-drug Interaction
HepaRG™ cells respond to prototypical P450 inducers and inhibitors to the same extent as primary hepatocytes, allowing HepaRG™ cells to be used to evaluate potential drug-drug interactions.

Infinitely Reproducible
HepaRG™ cells exhibit many characteristics of primary human hepatocytes and are essentially a single donor. These features allow users to obtain physiological relevant results for metabolism-based drug-drug interactions without the concern of donor variability and limited lot sizes that come with relying on donor tissue. (Note: The cells we provide are terminally differentiated).

HepaRG™ is a trademark of BioPredic International.

Specifications

• Content And Storage: 1 vial, store in cryostorage dewar or -135°C freezer
• Cell Line: HepaRG
• Form: Cryopreserved
• Species: Human
• No. of Cells: 10 x 10^6
• Quantity: 1 vial(s)

• Age: Adult
• Cell Type: Hepatocytes
• Gender: Female
• Donor Source: Single Donor
• Product Type: Hepatocytes
• Shipping Condition: Dry Ice

For Research Use Only. Not for use in diagnostic procedures.