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CD8a Mouse anti-Rat, PE, Clone: OX-8, BD

Mouse Monoclonal Antibody

$222.00 - $300.00

Specifications

Antigen CD8a
Clone OX-8
Concentration 0.2mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB559976
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BD Biosciences
559976
0.1 mg
Each for $222.00
Add to Cart
 
BDB554857
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BD Biosciences
554857
0.2 mg
Each for $300.00
Add to Cart
 
Description

Description

The OX-8 antibody reacts with the hinge-like membrane-proximal domain of the 32 kDa α chain of the CD8 differentiation antigen. A truncated CD8 α isoform has not been detected in the rat. The CD8 α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). Intestinal intrapithelial lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. OX-8 antibody does not react with resting CD4+ T helper cells. CD8 is an antigen coreceptor on the T-cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Ick. Macrophages have also been reported to express CD8 α and β chains, which are involved in signal transduction. Soluble OX-8 mAb partially blocks in vitro MLR and CTL activity.

Specifications

Specifications

CD8a
0.2mg/mL
Monoclonal
Mouse
Rat
High-molecular-weight rat thymocyte glycoproteins
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
OX-8
Flow Cytometry
PE
RUO
Aqueous buffered solution containing ≤0.09% sodium azide.
IgG1 κ
Affinity Purified
SDS
Documents

Documents

Product Certifications

For Research Use Only.

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