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CD8a Mouse anti-Rat, PE, Clone: OX-8, BD
Mouse Monoclonal Antibody
$222.00 - $300.00
Specifications
Antigen | CD8a |
---|---|
Clone | OX-8 |
Concentration | 0.2mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Description
The OX-8 antibody reacts with the hinge-like membrane-proximal domain of the 32 kDa α chain of the CD8 differentiation antigen. A truncated CD8 α isoform has not been detected in the rat. The CD8 α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopulation of mature T lymphocytes (i.e., MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). Intestinal intrapithelial lymphocytes, many CD8+ T cells of athymic rats, many activated CD4+ T cells, and most NK cells express CD8a without CD8b. It has been suggested that the expression of the CD8a/CD8b heterodimer is restricted to thymus-derived T lymphocytes. OX-8 antibody does not react with resting CD4+ T helper cells. CD8 is an antigen coreceptor on the T-cell surface which interacts with MHC class I molecules on antigen-presenting cells. It participates in T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase Ick. Macrophages have also been reported to express CD8 α and β chains, which are involved in signal transduction. Soluble OX-8 mAb partially blocks in vitro MLR and CTL activity.
Specifications
CD8a | |
0.2mg/mL | |
Monoclonal | |
Mouse | |
Rat | |
High-molecular-weight rat thymocyte glycoproteins | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
OX-8 | |
Flow Cytometry | |
PE | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified |
For Research Use Only.
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