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CD4a Mouse, FITC, Clone: 74-12-4, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559585

Catalog No. BDB559585


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Description

Description

The 74-12-4 (also known as clone PT4) monoclonal antibody specifically binds to CD4, a 55-kDa antigen expressed on T lymphocytes. This antibody does not react with CTL effectors, CTL precursors, or NK cells (ie, CD8[bright] cells) and it does not cross-react with human or bovine cells. Two peripheral T-helper lymphocyte phenotypes can be distinguished in the pig: CD4+CD8- and CD4+CD8[dull]. mAb 74-12-4 has been reported to inhibit proliferative responses of peripheral blood lymphocytes to mitogen, soluble antigen, and alloantigen. It is only marginally effective for in vivo depletion of peripheral CD4+ T cells. Two alloantigenic forms of CD4 have been recognized in miniature swine based upon their recognition (CD4.1) or lack of recognition (CD4.2) by mAb 74-12-4; the CD4.2 phenotype displays an autosomal recessive, non-MHC-linked, pattern of inheritance. The molecular basis for the polymorphism is a cluster of nucleotide differences leading to multiple amino-acid substitutions in the Ig CDR2-like loop structure. This mAb was clustered as anti-CD4a at the First International Swine CD Workshop. It has been reported to crossreact with chicken leukocytes.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD4a
Monoclonal
0.5mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
dd miniature swine thymocytes
0.1 mg
Immunology
Chicken, Porcine
IgG2b κ
Flow Cytometry
74-12-4
FITC
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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