CD220 Mouse anti-Human, PE, Clone: 3B6/IR, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559955

Catalog No. BDB559955

Description

Reacts with insulin receptor (IR), a glycoprotein composed of two extracellular α -subunits (130 kDa) and two transmembrane β -subunits (95 kDa). It is expressed on human hematopoietic and non-hematopoietic cells, but unlike the insulin-like growth factor receptor (IGF-IR), which is ubiquitous, the insulin receptor is restricted to major target tissues of insulin action. Upon binding insulin, the IR subunits form a heterotetramer of two α and two β subunits resulting in autophosphorylation and activation of the tyrosine kinase activity of the receptor. This ligand-receptor interaction is important in regulating cell metabolism and growth. 3B6/IR monoclonal antibody reacts similarly to anti-human IR α , clone 47-9, an α -subunit antibody.

Specifications

• Antigen: CD220
• Classification: Monoclonal
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Applications: Flow Cytometry
• Clone: 3B6/IR
• Description: Insulin Receptor, Insulin R
• Host Species: Mouse
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.