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CD141 Mouse anti-Human, PE, Clone: 1A4, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 559781

Catalog No. BDB559781


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Description

Description

The 1A4 monoclonal antibody specifically binds to a 75 kDa, a single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, dendritic cells, peripheral blood moncytes, and neutrophils, but not on lymphocytes. Reports indicate that CD141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD141
Monoclonal
PE
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Purified Human Thrombomodulin
100 Tests
Immunology
Human
IgG1 κ
Flow Cytometry
1A4
Thrombomodulin; TM; THBD; THRM; AHUS6; Fetomodulin; BDCA-3
Mouse
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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