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CD141 Mouse anti-Human, PE, Clone: 1A4, BD
Mouse Monoclonal Antibody
Supplier: BD Biosciences 559781
Description
The 1A4 monoclonal antibody specifically binds to a 75 kDa, a single chain, type I membrane glycoprotein referred to as thrombomodulin and fetomodulin. CD141 is expressed on endothelial cells, smooth muscle cells, epithelial cells, synovial lining cells, and keratinocytes. It is also found on megakaryocytes, dendritic cells, peripheral blood moncytes, and neutrophils, but not on lymphocytes. Reports indicate that CD141 plays an important role in Protein C activation and the initiation of the Protein C anticoagulant pathway. Thrombin loses its procagulant function when it binds to CD141, and the CD141/thrombin complex is able to activate Protein C.
Specifications
CD141 | |
Monoclonal | |
PE | |
Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
Purified Human Thrombomodulin | |
100 Tests | |
Immunology | |
Human | |
IgG1 κ |
Flow Cytometry | |
1A4 | |
Thrombomodulin; TM; THBD; THRM; AHUS6; Fetomodulin; BDCA-3 | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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