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Caspase-3 Rabbit, FITC, Clone: C92-605, BD

Rabbit Monoclonal Antibody

Supplier:  BD Biosciences 559341

Catalog No. BDB559341


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Description

Description

The caspase family of cysteine proteases plays a key role in apoptosis and inflammation. Caspase-3 is a key protease that is activated during the early stages of apoptosis and, like other members of the caspase family, is synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another protease. The processed forms of caspases consist of large (17-22 kDa) and small (10-12 kDa) subunits which associate to form an active enzyme. Active caspase-3, a marker for cells undergoing apoptosis, consists of a heterodimer of 17 and 12 kDa subunits which is derived from the 32 kDa pro-enzyme. Active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cytoplasm, e.g., D4-GDI and Bcl-2, and in the nucleus (e.g. PARP). This antibody has been reported to specifically recognize the active form of caspase-3 in human and mouse cells. It has not been reported to recognize the pro-enzyme form of caspase-3.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Caspase-3
Monoclonal
FITC
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Human Active Caspase-3 Fragment
100 Tests
Cell Biology
Human, Mouse
IgG
Flow Cytometry
C92-605
CPP32; Yama; Apopain
Rabbit
Affinity Purified
RUO
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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