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AIM 100, Tocris Bioscience™

Catalog Number 494650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
873305-35-2
C23H21N3O2
371.44
XNFHHOXCDUAYSR-SFHVURJKSA-N
s-5,6-diphenyl-n-tetrahydrofuran-2-yl methyl furo 2,3-d pyrimidin-4-amine, 5,6-diphenyl-4-s-tetrahydrofuran-2-yl-methyl amino furo 2,3-d pyrimidine, 5,6-diphenyl-n-2s-tetrahydro-2-furanyl methyl furo 2,3-d pyrimidin-4-amine, 5,6-diphenyl-n-2s-tetrahydrofuran-2-yl methyl furo 2,3-d pyrimidin-4-amine, n-2s-oxolan-2-ylmethyl-5,6-diphenylfuro 2,3-d pyrimidin-4-amine
11501591
N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
C1CC(OC1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5
This item is not returnable. View return policy
873305-35-2
C23H21N3O2
371.44
XNFHHOXCDUAYSR-SFHVURJKSA-N
s-5,6-diphenyl-n-tetrahydrofuran-2-yl methyl furo 2,3-d pyrimidin-4-amine, 5,6-diphenyl-4-s-tetrahydrofuran-2-yl-methyl amino furo 2,3-d pyrimidine, 5,6-diphenyl-n-2s-tetrahydro-2-furanyl methyl furo 2,3-d pyrimidin-4-amine, 5,6-diphenyl-n-2s-tetrahydrofuran-2-yl methyl furo 2,3-d pyrimidin-4-amine, n-2s-oxolan-2-ylmethyl-5,6-diphenylfuro 2,3-d pyrimidin-4-amine
11501591
N-[[(2S)-oxolan-2-yl]methyl]-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine
C1CC(OC1)CNC2=C3C(=C(OC3=NC=N2)C4=CC=CC=C4)C5=CC=CC=C5

Description

Potent and selective Ack1 (TNK2) inhibitor

Potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.
Quantity 50 mg
Formula Weight 371.43
Chemical Name or Material AIM 100

Safety and Handling

Recommended Storage Store at +4°C
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