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Tocris Bioscience™ AC 710
Potent and selective PDGFR family inhibitor
$381.64 - $1598.48
Specifications
Purity | >99% |
---|---|
Description | AC 710 |
Molecular Weight (g/mol) | 562.7 |
Product Type | AC 710 |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-131-0RD
|
Tocris Bioscience™
5013/10 |
10 mg |
Each for $381.64
|
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50-135-0RD
|
Tocris Bioscience™
5013/50 |
50 mg |
Each for $1,598.48
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Description
Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.Specifications
>99% | |
AC 710 | |
562.7 | |
AC 710 |
For Research Use Only
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