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Tocris Bioscience™ AC 710

Potent and selective PDGFR family inhibitor

$381.64 - $1598.48

Specifications

Purity >99%
Description AC 710
Molecular Weight (g/mol) 562.7
Product Type AC 710
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-131-0RD
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Tocris Bioscience™
5013/10
10 mg
Each for $381.64
Add to Cart
 
50-135-0RD
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Tocris Bioscience™
5013/50
50 mg
Each for $1,598.48
Add to Cart
 
Description

Description

Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
Specifications

Specifications

>99%
AC 710
562.7
AC 710
SDS
Documents

Documents

Product Certifications

For Research Use Only

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