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2-APB, Tocris Bioscience™

Catalog Number 122450
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
524-95-8
C14H16BNO
225.10
MFCD00014823
BLZVCIGGICSWIG-UHFFFAOYSA-N
2-aminoethyl diphenylborinate, 2-apb, 2-aminoethoxy diphenylborane, 2-aminoethoxydiphenylborane, 2-aminoethoxydiphenylborate, 2-aminoethoxydiphenyl borate, o-2-aminoethyl diphenylborinic acid, b-2-aminoethoxy diphenylborane, 2-diphenylboryl oxy ethanamine, borinic acid, o-2-aminoethyl diphenyl
1598
2-aminoethyl diphenylborinate
NCCOB(C1=CC=CC=C1)C1=CC=CC=C1
This item is not returnable. View return policy
524-95-8
C14H16BNO
225.10
MFCD00014823
BLZVCIGGICSWIG-UHFFFAOYSA-N
2-aminoethyl diphenylborinate, 2-apb, 2-aminoethoxy diphenylborane, 2-aminoethoxydiphenylborane, 2-aminoethoxydiphenylborate, 2-aminoethoxydiphenyl borate, o-2-aminoethyl diphenylborinic acid, b-2-aminoethoxy diphenylborane, 2-diphenylboryl oxy ethanamine, borinic acid, o-2-aminoethyl diphenyl
1598
2-aminoethyl diphenylborinate
NCCOB(C1=CC=CC=C1)C1=CC=CC=C1

Description

IP3 receptor antagonist. Also TRP channel modulator

A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.
Quantity 50 mg
Formula Weight 225.1
Percent Purity >98%
Chemical Name or Material 2-APB

Safety and Handling

Recommended Storage Store at Room Temperature
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