Hs04020929_cn

• Gene Symbol: TCF3
• Assay Reference Genome Location: Chr.19:1616887 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6929
• Gene Name: transcription factor 3
• Gene Aliases: AGM8, E2A, E47, ITF1, TCF-3, VDIR, bHLHb21
• Location: Chr.19:1609290-1652590 on Build GRCh38
• Assay Gene Location: Within Intron 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TCF3	NM_001136139.2			NP_001129611.1
	NM_003200.3			NP_003191.1
	XM_006722852.3			XP_006722915.1
	XM_006722853.3			XP_006722916.1
	XM_006722855.3			XP_006722918.1
	XM_006722856.3			XP_006722919.1
	XM_006722857.3			XP_006722920.1
	XM_006722858.3			XP_006722921.1
	XM_011528215.2			XP_011526517.1
	XM_011528216.2			XP_011526518.1
	XM_011528217.2			XP_011526519.1
	XM_011528219.2			XP_011526521.1
	XM_011528220.2			XP_011526522.1
	XM_011528221.2			XP_011526523.1
	XM_011528223.2			XP_011526525.1
	XM_011528225.2			XP_011526527.1
	XM_011528226.2			XP_011526528.1
	XM_011528227.2			XP_011526529.1
	XM_017027177.1			XP_016882666.1
	XM_017027178.1			XP_016882667.1
	XM_017027179.1			XP_016882668.1
	XM_017027180.1			XP_016882669.1
	XM_017027181.1			XP_016882670.1
	XM_017027182.1			XP_016882671.1
	XM_017027183.1			XP_016882672.1
	XM_017027184.1			XP_016882673.1
	BC011665.2			AAH11665.1
	BC110580.1			AAI10581.1
	BG284440.1
	KF303591.1
	M24404.1			AAA56829.1
	M24405.1			AAA56830.1
	M31523.1			AAA61146.1
	X52078.1			CAA36297.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	BTBD2 TCF3 SCAMP4 ABHD17A CSNK1G2-AS1 MEX3D MBD3 CSNK1G2 C19orf25 MIR1909 REEP6 APC2 ATP8B3 PLK5 KLF16 ADAMTSL5 MUM1 ADAT3 DAZAP1 REXO1 ONECUT3 NDUFS7 LOC100288123 UQCR11 GAMT RPS15 PCSK4
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	BTBD2 TCF3 SCAMP4 ABHD17A CSNK1G2-AS1 MEX3D MKNK2 MBD3 CSNK1G2 C19orf25 MIR1909 REEP6 APC2 ATP8B3 PLK5 KLF16 ADAMTSL5 MUM1 ADAT3 DAZAP1 REXO1 ONECUT3 NDUFS7 LOC100288123 UQCR11 GAMT RPS15 PCSK4

More Information

Additional Information:

For this assay, SNP(s) [rs75786300] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
B cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
B cell differentiation
immunoglobulin V(D)J recombination
positive regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
mitogen-activated protein kinase kinase kinase binding
enhancer binding
protein homodimerization activity
bHLH transcription factor binding
protein heterodimerization activity
repressing transcription factor binding
vitamin D response element binding
E-box binding