Hs00827004_cn

• Gene Symbol: TCF7L2
• Assay Reference Genome Location: Chr.10:112950803 on build GRCh38
• Cytoband: 10q25.2

Target Gene Details

• Entrez Gene ID: 6934
• Gene Name: transcription factor 7 like 2
• Gene Aliases: TCF-4, TCF4
• Location: Chr.10:112950219-113167678 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TCF7L2	NM_001146274.1	1	554	NP_001139746.1
	NM_001146283.1	1	554	NP_001139755.1
	NM_001146284.1	1	554	NP_001139756.1
	NM_001146285.1	1	554	NP_001139757.1
	NM_001146286.1	1	554	NP_001139758.1
	NM_001198525.1	1	554	NP_001185454.1
	NM_001198526.1	1	554	NP_001185455.1
	NM_001198527.1	1	554	NP_001185456.1
	NM_001198528.1	1	554	NP_001185457.1
	NM_001198529.1	1	554	NP_001185458.1
	NM_001198530.1	1	554	NP_001185459.1
	NM_001198531.1	1	554	NP_001185460.1
	NM_030756.4	1	554	NP_110383.2
	XM_005270071.1	1	585	XP_005270128.1
	XM_005270075.1	1	585	XP_005270132.1
	XM_005270077.1	1	585	XP_005270134.1
	XM_005270078.1	1	585	XP_005270135.1
	XM_005270079.1	1	585	XP_005270136.1
	XM_005270080.1	1	585	XP_005270137.1
	XM_005270084.1	1	585	XP_005270141.1
	XM_005270085.1	1	585	XP_005270142.1
	XM_005270086.1	1	585	XP_005270143.1
	XM_005270088.1	1	585	XP_005270145.1
	XM_005270089.1	1	585	XP_005270146.1
	XM_005270091.2	1	585	XP_005270148.1
	XM_005270092.1	1	585	XP_005270149.1
	XM_005270093.2	1	585	XP_005270150.1
	XM_005270094.2	1	585	XP_005270151.1
	XM_005270095.1	1	585	XP_005270152.1
	XM_005270096.2	1	585	XP_005270153.1
	XM_005270100.1	1	585	XP_005270157.1
	XM_005270101.2	1	585	XP_005270158.1
	XM_005270102.1	1	585	XP_005270159.1
	XM_005270103.1	1	585	XP_005270160.1
	XM_005270104.1	1	585	XP_005270161.1
	XM_011540109.1	1	585	XP_011538411.1
	XM_011540110.1	1	585	XP_011538412.1
	XM_011540111.1	1	585	XP_011538413.1
	XM_011540113.2	1	585	XP_011538415.1
	XM_011540116.1	1	585	XP_011538418.1
	XM_017016584.1	1	585	XP_016872073.1
	XM_017016585.1	1	585	XP_016872074.1
	XM_017016586.1	1	585	XP_016872075.1
	XM_017016587.1	1	585	XP_016872076.1
	XM_017016588.1	1	585	XP_016872077.1
	XM_017016589.1	1	585	XP_016872078.1
	XM_017016590.1	1	585	XP_016872079.1
	XM_017016591.1	1	585	XP_016872080.1
	XM_017016592.1	1	585	XP_016872081.1
	XM_017016593.1	1	585	XP_016872082.1
	XM_017016594.1	1	585	XP_016872083.1
	XM_017016595.1	1	585	XP_016872084.1
	XM_017016596.1	1	585	XP_016872085.1
	AB440195.1
	AB451266.1
	AK225809.1	1	557
	AK299295.1	1	83
	AK315243.1	1	218
	BC032656.1	1	142	AAH32656.1
	CR536574.1			CAG38811.1
	DA473655.1
	FJ010166.1	1	140
	FJ010167.1	1	140
	FJ010168.1	1	144
FJ010169.1	1	144
FJ010170.1	1	140
FJ010171.1	1	84
FJ010172.1	1	144
FJ010174.1	1	502
HM352838.1
HM352839.1
HM352840.1
HM352841.1
HM352842.1
HM352843.1
HM352844.1
HM352845.1
HM352846.1
HM352847.1
HM352848.1
HM352849.1
HM352850.1
HM352851.1
Y11306.2	1	354	CAA72166.2

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv518n106	Chr.10:112949441 - 112951941 on Build GRCh38	Deletion	TCF7L2
nsv1070891	Chr.10:112949140 - 112951941 on Build GRCh38	Deletion	TCF7L2

More Information

Additional Information:

For this assay, SNP(s) [rs373426839,rs76088094] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle arrest
Wnt signaling pathway, calcium modulating pathway
cell proliferation
response to glucose
positive regulation of heparan sulfate proteoglycan biosynthetic process
pancreas development
positive regulation of insulin secretion
positive regulation of protein binding
regulation of hormone metabolic process
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
maintenance of DNA repeat elements
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein export from nucleus
myoblast fate commitment
regulation of smooth muscle cell proliferation
positive regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
beta-catenin-TCF complex assembly
negative regulation of type B pancreatic cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
transcription factor binding
protein kinase binding
nuclear hormone receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
gamma-catenin binding
armadillo repeat domain binding