The panel of assays in the TaqMan® Array 96-well Human Ligand Gated Ion Channels Plate targets genes in the 3 superfamilies of the ligand-gated channels: 1) The Cys-loop receptors (GABAA receptor family, Glycine Receptor family, 5-HT Receptors/Serotonin, and Nicotinic acetylcholine receptor family); 2) The Ionotropic glutamate receptors (AMPA, Kainate, NMDA); and 3) The ATP-gated Channels (P2X receptors). Also in the panel are genes which encode Ion channel family members: Ch ...loride channel, TRP (transient receptor potential) cation channels, Calcium Channel, and Sodium Channel. Additionally one gene from the Cyclic nucleotide-gated channel and Potassium gated ion channel are also present.
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ACCN1, ACCN2, ACCN3, CFTR, CHRNA1, CHRNA2, CHRNA3, CHRNA4, CHRNA6, CHRNA9, CHRNB1, CHRNB2, CHRNB3, CHRNB4, CHRND, CHRNE, CLCN1, CLCN2, CLCN4, CLCN5, CLCN6, CLCN7, CLCNKA, CLCNKB, CLIC1, CLIC3, CLIC4, CLIC5, CLIC6, CNGA3, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG...2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GLRA1, GLRA2, GLRA3, GLRB, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIN3A, HCN3, HCN4, HTR3A, HTR3B, ITPR1, ITPR3, KCNA10, P2RX1, P2RX2, P2RX3, P2RX4, P2RX7, PKD2, PKD2L1, RYR1, RYR2, RYR3, SCNN1A, SCNN1B, SCNN1D, SCNN1G, TRPC1, TRPC3, TRPC4, TRPC5, TRPC6
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Ligand-gated channels or ionotropic receptors are a group of membrane ion channels that respond to chemical signal (the ligand) by opening or closing. The ion channels are selective to ions such as Na+, K+, Ca2+, or Cl-. A major function of ligand-gated ...channels is to convert chemical signals such as a synaptically released neurotransmitter into electrical signals.
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