Invitrogen
Catalog # PA5-50520
Quantity:
TESTED APPLICATIONS | DILUTION |
---|---|
Immunohistochemistry (Paraffin) (IHC (P)) | 1:50-1:200 |
Western Blot (WB) | 1:1,000-1:5,000 |
Species reactivity | Human, Mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Synthetic peptide corresponding to residues near the N terminal of human ATP-binding cassette, sub-family C |
Conjugate | Unconjugated |
Form | Liquid |
Concentration | 1.9 mg/mL |
Purification | Antigen affinity chromatography |
Storage buffer | PBS, pH 7.4, with 40% glycerol |
Contains | 0.05% sodium azide |
Storage conditions | -20°C |
RRID | AB_2635973 |
The antibody detects endogenous levels of total ABCC5 protein.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABC 33; ABCC 5; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5a; ATP-binding cassette, sub-family C (CFTR/MRP), member 5b; ATP-binding cassette, sub-family C, member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; MOAT C; MOAT-C; MRP 5; Multi-specific organic anion transporter C; Multidrug resistance-associated protein 5; pABC 11; pABC11; SMRP
Gene Aliases: 2900011L11Rik; ABC33; ABCC5; Abcc5a; Abcc5b; AI132311; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
UniProt ID: (Human) O15440, (Mouse) Q9R1X5
Entrez Gene ID: (Human) 10057, (Mouse) 27416
Molecular Function: ATP-binding cassette (ABC) transporter
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